ISSN: 2329-888X
+44 1300 500008
Avi Shamay
Israel
Research Article
Lipid Metabolism in Mammary Epithelial Cells-A Comparison of Common In vitro Models
Author(s): Bat-Chen Cohen, Avi Shamay and Nurit Argov-ArgamanBat-Chen Cohen, Avi Shamay and Nurit Argov-Argaman
One of the main cellular functions of mammary epithelial cells (MEC) is the vast production of lipids to provide the new born with the energy and bioactive molecules that are essential for its development and survival. Milk lipids are secreted in a structure termed milk fat globule (MFG) which buds from the MEC, enveloped with the cellular bilayer membrane. MFG membrane composition changes as a function of lactation stage, nutrition and MFG size. In addition, MFG size differs at different stages of lactation and in response to nutritional treatments. Therefore, it is hypothesized that the MEC membrane changes according to metabolic and hormonal signals in the animal's body, and that these changes are associated with milk lipid production and secretion and MFG size. The aim of this work was to find a suitable model for studying lipogenic activity and its relation to membrane compositio.. View More»
DOI:
10.4172/2329-888X.1000202