Journal of Leukemia
Open Access

Ayman Elsheik

Publications

• Research Article
  Protective Effect of Nigella sativa Oil against Methotrexate Induced Hepatotoxicity in Children with Acute Lymphoblastic Leukemia
  Author(s): Adel A Hagag, Ahmed M Abd Elaal, Ayman Elsheik and Enas Arafa Elzamarany Adel A Hagag, Ahmed M Abd Elaal, Ayman Elsheik and Enas Arafa Elzamarany
  
  Background: Acute Lymphoblastic Leukemia (ALL) is the most common childhood malignancies representing about one third of all pediatric cancers. Adding methotrexate to leukemia treatment protocols has been associated with an increased survival rate in children with ALL. The efficacy of this agent is often limited by its toxicity which can be reduced if supplemented with anti-oxidants. Nigella sativa has antioxidant property through different mechanisms. Objective: The aim of this work was to study the role of Nigella sativa oil in the protection against hepatotoxicity induced by methotrexate therapy in children with ALL and the impact on the treatment outcome. Patients and methods: The present study was conducted in the period between July 2010 and July 2013 on 40 children with newly diagnosed ALL including 28 males and 12 females, with mean age value of 9.17 ± 3.81 years and they were di.. View More»
  DOI: 10.4172/2329-6917.1000123

  Abstract PDF

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