Drug Designing: Open Access
Open Access

Azhar Mehmood

Publications

• Research Article
  Structure-Based Pharmacophore Modeling, Virtual Screening and Molecular docking for the Treatment of ESR1 Mutations in Breast Cancer
  Author(s): Anum Munir, Shumaila Azam, Azhar Mehmood, Zanib Khan, Arshad Mehmood and Sahar FazalAnum Munir, Shumaila Azam, Azhar Mehmood, Zanib Khan, Arshad Mehmood and Sahar Fazal
  
  Background: Mutations of Estrogen receptors 1 affect its ligand-binding domain and results in the formation of breast cancer. Breast cancer is a known universal disease and the second leading reason behind the death of most females. About 70% of breast cancers express the estrogen receptor. This study was undertaken to realize perceptions into molecular mechanisms and structural necessities that are crucial for potential inhibition of ESR1. Methods: In this research ESR1 proteins were selected and pharmacophore models were generated, virtual screening was done to obtain hit compounds against reference shared feature pharmacophore, the hit compounds were docked with ESR1 proteins. Results: The pharmacophore displayed three main features Hydrogen bond acceptor, Hydrogen bond donor and aromatic rings. 10 hit compounds wer.. View More»
  DOI: 10.4172/2169-0138.1000137

  Abstract PDF

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