Medicinal & Aromatic Plants
Open Access

Azza H El-Medany

Publications

• Research Article
  Expanding the Therapeutic Utility of Curcumin: An Experimental Study on DMH-induced Colorectal Cancer
  Author(s): Azza H El-Medany, Hanan H Hangar, Omnia A Nayel1 and Jamila H El-Medany Azza H El-Medany, Hanan H Hangar, Omnia A Nayel1 and Jamila H El-Medany
  
  search for drugs that can target cancer cell microenvironment in as much as being able to halt malignant cellular transformation, the natural dietary phytochemical curcumin was currently assessed in DMH-induced colorectal cancer rat model. The study enrolled 50 animals divided into a control group (n=10) and DMH-induced colorectal cancer control group (n=20) (20 mg/kg.-body weight for 28 weeks) versus curcumin-treated group (n=20) (160 mg/kg suspension daily oral for further 8 weeks). Treatment by curcumin succeeded to significantly decrease the percent of ACF and tended to normalize back the histological changes retrieved in adenomatous and stromal cells induced by DMH. The drug also significantly elevated GSH and significantly reduced most of the accompanying biochemical elevations (namely MDA, TNF-α, TGF-β and COX2) observed in colonic carcinomatous tissue, induced by DM.. View More»
  DOI: 10.4172/2167-0412.1000310

  Abstract PDF

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