Department of Radiological Sciences, University of California, Irvine, CA, USA
Biography
This study investigates the use of [F-18]RGD-K5, an integrin αvβ3 targeting PET tracer, in breast cancer patients receiving chemotherapy with bevacizumab (Avastin®). Two patients were analyzed: Subject-1 had metastatic breast cancers and Subject-2 had a primary cancer in the breast. The therapy regimen was weekly paclitaxel and carboplatin combined with bi-weekly bevacizumab. Each subject received 5 PET-CT scans: pre-treatment [F-18]RGD-K5 and [F-18]FDG, one [F-18]RGD-K5 F/U scan after 2 doses of bevacizumab, and another [F-18]RGD-K5 and [F-18] FDG F/U after 4 doses of bevacizumab.
