Clinical & Experimental Cardiology
Open Access

BaktiarKidwai

Publications

• Research Article
  Comparative Analysis of Plaque Growth after Arterial Stent Implant with Anti-Inflammatory Chemokine and Serine Protease Inhibitors Treatment
  Author(s): Liying Liu, Erbin Dai, BaktiarKidwai, Jennifer Davids, Colin Macaulay, Grant McFadden, and Alexandra Lucas Liying Liu, Erbin Dai, BaktiarKidwai, Jennifer Davids, Colin Macaulay, Grant McFadden, and Alexandra Lucas
  
  Rationale -Inflammation is up-regulated at sites ofstent implant, whether bare metal or drug-eluting stents (DES), increasingneointimal plaque growth (termed restenosis). Although stent implant,, particularly DES, reduces recurrent plaque growth, restenosis still occurs. Inflammatory macrophages and T lymphocytes invadesites withendothelial injury and implanted foreign metal and polymersincreaseendothelial dysfunction, plaque growthand thrombosis. Chemokines attract inflammatory cells and coagulation pathway serine proteases regulate clot formation, metalloproteases, and inflammation. Large DNA viruses secrete highly active immune modulators that block host defenses, some of which are potent inhibitors of pathways that drive restenosis. We examine here two virus-derived anti-inflammatory proteins as potential anti-restenosis agents in a rabbit angioplasty and stent implant model;1) M-.. View More»
  DOI: 10.4172/2155-9880.1000274

  Abstract PDF

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