Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Barak Reicher
Israel
Review Article
WASp and WAVE Proteins: From Structure, Through Function, to Clinical Aspects
Author(s): Barak Reicher, Orly Perl, Omri Matalon and Mira Barda-SaadBarak Reicher, Orly Perl, Omri Matalon and Mira Barda-Saad
T cells play a pivotal role in adoptive immunity, both in cell mediated cytotoxicity and in the activation of the humoral immune response. In order to perform their effector function, T cells undergo dramatic morphological changes upon activation. These changes enable their binding to and extravasation through the vascular endothelium into the neighboring tissue, the formation of an immunological synapse (IS) with an antigen-presenting cell (APC), and subsequently, the polarized secretion of cytokines and/or cytolytic granules, leading to the execution of effector functions.
The actin cytoskeleton is directly involved in all these processes. Thus, it is crucial for T cell mediated immune responses, providing a dynamic and flexible platform for signal transduction, cellular and subcellular remodeling, and for driving effector functions. The actin-regulatory proteins, Wiskott-Al.. View More»
DOI:
10.4172/2155-9899.S12-001