Journal of Depression and Anxiety
Open Access

Barbara Heckel

Publications

• Review Article
  Individualized Pharmacological Treatment of Depressive Disorders State of the Art and Recent Developments
  Author(s): Thomas C Baghai, Christina Zirngibl, Barbara Heckel, Nina Sarubin and Rainer RupprechtThomas C Baghai, Christina Zirngibl, Barbara Heckel, Nina Sarubin and Rainer Rupprecht
  
  During the past decade a variety of promising new compounds were launched onto the market. These are influencing serotonergic, noradrenergic, and dopaminergic neurotransmission, and interact with melatonergic and serotonergic receptor systems. The main advantages of all newer drugs are a broadening of the spectrum of available treatments, better safety and tolerability profiles in comparison to older compounds and the focus on specific symptoms of depression including insomnia and cognitive disturbances. Still unresolved issues are the relatively high non-response rate during the first weeks of antidepressant treatments, a latency of sometimes several weeks until clinical improvement and remission can be achieved, and a variety of possible side effects also present during treatment with modern compounds. Still unresolved issues are the relatively high non-respo.. View More»
  DOI: 10.4172/2167-1044.1000154

  Abstract PDF

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