Journal of Clinical and Cellular Immunology
Open Access

Béatrice Gaugler

Publications

• Research Article
  Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis
  Author(s): Beatrice Gaugler, Caroline Laheurte, Ewa Bertolini, Aurore Pugin, Daniel Wendling, Philippe Saas, Eric Toussirot on behalf of CBT-506 Beatrice Gaugler, Caroline Laheurte, Ewa Bertolini, Aurore Pugin, Daniel Wendling, Philippe Saas, Eric Toussirot on behalf of CBT-506
  
  Background: To evaluate the distribution of circulating B cell subsets and their expression of BAFF/APRIL receptors (BAFF-R, TACI and BCMA) as well as circulating levels of BAFF and APRIL in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) compared to healthy controls (HC). Methods: 59 patients with RA, 61 patients with AS and 61 HC were evaluated. All patients were receiving traditional treatments and had not received prior biological treatment. Peripheral blood B cell subsets were assessed using multicolor flow cytometry using CD27, CD38 and IgD staining. Expression of BAFF-R, TACI and BCMA was analyzed on each cell subset. Results: Distribution of peripheral B cells subsets was disturbed in RA compared to HC, with a decreased proportion of naïve and transitional B cells (p<0.005), whereas.. View More»
  DOI: 10.4172/2155-9899.1000163

  Abstract PDF

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