Journal of Proteomics & Bioinformatics
Open Access

Bernard Chen

Publications

• Research Article
  An Accurate Genomic Island Prediction Method for Sequenced Bacterial and Archaeal Genomes
  Author(s): Dongsheng Che, Han Wang, John Fazekas and Bernard ChenDongsheng Che, Han Wang, John Fazekas and Bernard Chen
  
  A genomic island (GI) is a genomic segment in a host genome, and it was transferred from donor genomes. Since genomic islands (GIs) usually contain important genes such as pathogenicity genes, the detection of GIs becomes extremely critical to medical research and industrial applications. Previous computational GI detection tools used one or a few GI-associate features, and thus they suffered the problem of low prediction accuracy. A systematic approach that uses multiple sources to improve GI prediction accuracy, therefore, is in great demand. In this paper, we report the development of Genomic Island Hunter (GIHunter), an accurate software tool for GI detection. GIHunter is a decision tree based bagging model that uses eight GI-associated features such as sequence composition, mobile gene information, and integrase. The performance metric comparison between our approach and other cu.. View More»
  DOI: 10.4172/jpb.1000322

  Abstract PDF

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