Rheumatology: Current Research
Open Access

Bernhard Ryffel

Publications

• Editorial
  Foxp3+ Regulatory T Cells: a Protagonist in the “Movie’’ of Autoimmune Diseases?
  Author(s): Anping Xu, Ya Liu, Bernhard Ryffel, Song Guo ZhengAnping Xu, Ya Liu, Bernhard Ryffel, Song Guo Zheng
  
  Although CD4+CD25+Foxp3+ regulatory or suppressor T cells (Tregs) play a crucial role in the maintenance of self-tolerance and immune homeostasis against self-antigen, the true role they play in autoimmune diseases is still less defined. The prospect for therapeutic roles of these cells in autoimmune diseases is somehow fuzzy. This editorial will discuss and update these issues and proposes several new directions to address the relative concerns. Thymus-derived, naturally-occurring CD4+CD25+ suppressor cells (nTregs) were originally described by Sakaguchi and his colleagues where they identified that CD4+CD25+ cells in the thymus are crucial for the control of autoimmunity [1]. As CD25 is also activation marker for lymphocytes and therefore its expression is unable to exclude other T effector (Teff) cell population that may contaminate Tregs. Subsequent studies have demonstrated that .. View More»
  DOI: 10.4172/2161-1149.1000e102

  Abstract PDF

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