ISSN: 2155-9554
+44 1478 350008
Bola A. Adeniyi
Ibadan
Nigeria
Research
Anti-Dermatophytic Potential of Formulated Extract of Cola nitida (Vent.) Schott& Endl. (Stem Bark)
Author(s): Olakunle O. Mebude, Temitope. O. Lawal and Bola A. AdeniyiOlakunle O. Mebude, Temitope. O. Lawal and Bola A. Adeniyi
The antifungal activities of stem bark ethanolic extract of Cola nitida [Vent.) Schott & Endl. against fungi associated with dermatophytes was determined in vitro by agar cup diffusion, agar dilution technique, and time kill assay. The result showed that the extract at concentrations ranging between 6 mg/mL to 0.5 mg/mL produced zone of inhibition between 10 ± 0.1 and 25 ± 0.2 mm against the test fungi. The MIC and MFC of the extract ranged from 22.5 to 3120 µg/mL and 45 to 3120 µg/mL respectively. The MICs for Trichophyton rubrum and T. tonsurans were less than 100 µg/mL and the mechanism of antibiosis indicated that the formulated ethanolic extract was highly fungicidal. Since lower MIC and MFC indicates higher efficacy, the MIC/MFC in this study are within the range of ≤ 100 and ≥ 1000 µg/mL. .. View More»
DOI:
10.4172/2155-9554.1000394