Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Botros Gerges
Egypt
Research Article
The TH17/Treg Imbalance in Rheumatoid Arthritis and Relation to Disease Activity
Author(s): Taghrid Gaafar, Reem Farid, Hala Raafat, Faten Bayoumi, Botros Gerges and Dina RasheedTaghrid Gaafar, Reem Farid, Hala Raafat, Faten Bayoumi, Botros Gerges and Dina Rasheed
Objectives: T regulatory cells (Treg) and proinflammatory TH17 cells are newly identified T lymphocyte subsets, which have significant effects on autoimmunity and inflammation. Tregs play key role in the maintenance of self-tolerance. TH17/Treg disturbed balance has been reported to contribute to several autoimmune diseases.Our aim was to assess the Treg/TH17 pattern and TH17 related cytokines, in peripheral blood of Egyptian rheumatoid arthritis patients, and their relation to disease activity score (DAS). Analyzing IL17A and IL23 as indicators of TH17 function, was to study the effect of TH17 in RA.Methods: 100 Egyptian rheumatoid arthritis patients, divided into Group I (14), Group II (48), Group III (38), with low <3.2, moderate 3.2 to <5.1 and high >5.1, activi.. View More»
DOI:
10.4172/2155-9899.1000381