Chemotherapy: Open Access
Open Access

Bozok-Cetintas V

Publications

• Research Article
  Investigation of the Cell Stabilization and the Epithelial to Mesenchymal Transition Effect of Flavopiridol in Mouse Lung Squamous Cell Carcinoma
  Author(s): Aktug H, Acikgoz E, Yigitturk G, Demir K, Oktem G, Oltulu F and Bozok-Cetintas V Aktug H, Acikgoz E, Yigitturk G, Demir K, Oktem G, Oltulu F and Bozok-Cetintas V
  
  Abstract Background: Lung malignancy is a leading cause of cancer related morbidity and mortality worldwide. The three main subtypes of Non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell lung cancers (SqCLCs) and large-cell carcinoma. Flavopiridol is a flavone that inhibits several cyclindependent kinases and exhibits potent growthinhibitory activity, apoptosis and G1 phase arrest in a number of human tumor cell lines. The present study focused on the effect of flavopiridol in cell stabilization, cell adhesion, junctional complex and epithelial to mesenchymal transition (EMT) in mouse lung squamous cell carcinoma cell. Methods: Cell viability and proliferation of untreated controls and flavopiridol treated cells were determined by using the WST-1 assay. SqCLCs and M. dunni mouse skin fibroblast cells (MSF) cells immunofluorescence analyses were performed for the evaluat.. View More»
  DOI: 10.4172/2167-7700.1000171

  Abstract PDF

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