Journal of Clinical and Experimental Ophthalmology
Open Access

Brett Weinstock

Publications

• Research Article
  Clinical and Immunohistochemical Features of Sebaceous Carcinoma: Focusing on the p53 Tumor Suppressor
  Author(s): Gobind Singh, Brett Weinstock, Robert G. Phelps and Albert Y Wu Gobind Singh, Brett Weinstock, Robert G. Phelps and Albert Y Wu
  
  Purpose: Considerable focus has recently revealed the importance of p53 in sebaceous carcinoma (SC). This study investigates the utility of p53 as an immunohistochemistry (IHC) marker for differentiating benign and malignant sebaceous tissues and reports the clinical characteristics of patients diagnosed with SC at Mount Sinai Hospital (MSH). Methods: A retrospective chart analysis of 102 patients with SC was performed in addition to a histopathological examination of benign and malignant sebaceous tissues. Immunohistochemistry was performed in 30 cases of SC, 4 cases of sebaceous hyperplasia, 4 cases of sebaceous epitheliomas, and 3 cases of sebaceous adenoma. A separate outpatient cohort was used to compare the clinical and histologic features of eyelid lesions. This included 31 available cases with histologic descriptions of SC. The clinical features of 20 SC cases, 25 BCC cases, a.. View More»
  DOI: 10.4172/2155-9570.1000635

  Abstract PDF

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