ISSN: 2329-8731
+44 1300 500008
Brian Godman
Division of Clinical Pharmacology Karolinska Institutet,
Sweden
Research Article
The Potential Effect of Using the Cockcroft-Gault Method on Tenofovir-Associated Renal Impairment Reports and on Clinical Decisions Regarding Tenofovir Use in Individual Patients: Implications for the Future
Author(s): Francis Kalemeera, Marike Cockeran, Mwangana Mubita, Dan Kibuule, Ester Naikaku, Amos Massele and Brian GodmanFrancis Kalemeera, Marike Cockeran, Mwangana Mubita, Dan Kibuule, Ester Naikaku, Amos Massele and Brian Godman
Introduction: In Namibia, the Cockcroft-Gault (C-G) method is recommended for monitoring renal function in HIV patients receiving Tenofovir Disoproxil Fumarate (TDF)-containing Combination Antiretroviral Therapy (cART). However, there are concerns with the potential over-reporting of TDF-associated renal impairment.
Methods: Retrospective study comparing the renal function of patients receiving 2nd line cART with either C-G or Chronic Kidney Disease-Epidemiology (CKD-EPI) methods.
Results: 71 patients were included. The majority (62%) received TDF-containing 1st line ART. All received 2ndline cART containing TDF/Lamivudine (3TC)/Zidovudine (AZT) and LPV/r. Before switching to 2nd-line cART, 40.8% and 8.5% had abnormal eGFR according to C-G and CKD-EPI methods respectively. During 2nd-line cART, 47.9% and 7% of pati.. View More»
DOI:
10.4172/2329-8731.1000170