Chemotherapy: Open Access
Open Access

Bruno Maras

Publications

• Commentary
  Resistance in Candida albicans: Exploring the Cell Wall Barrier by Proteomics
  Author(s): Bruno Maras, Giuseppina Mignogna and Letizia Angiolella Bruno Maras, Giuseppina Mignogna and Letizia Angiolella
  
  The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients. Azole and echinocandin drug resistance accounts for the dramatic increase in incidence of nosocomial bloodstream candidiasis found in recent years. Cell wall constitutes the barrier between the yeast and the host and resistant strains change the proteome of this compartment. In the last decade different proteomic platforms have been applied to study cell wall and markers of resistance to drugs have been pointed out. Modulation of these proteins seem to suggest that although resistance is based on a specific mutation able to counteract the toxicity of the antifungal drug, a set of other molecular modifications takes place contemporary or subsequently the establishment o.. View More»
  DOI: 10.4172/2167-7700.1000165

  Abstract PDF

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