Journal of Clinical Toxicology
Open Access

Byung Sun Yoo

Publications

• Research Article
  Benzopyrene Inhibits Differentiation of Human SH-SY5Y Neuroblastomain Culture in Cells
  Author(s): Do Eun Kim and Byung Sun Yoo* Do Eun Kim and Byung Sun Yoo*
  
  Benzopyrene (BaP) is polycyclic aromatic hydrocarbon (PAH), and is chemically modified in the animal body to form a number of metabolites that may elicit a various toxicity. However, the effect of BaP on neuroblastoma differentiation has remained unclear. We have studied the effect of BaP on neurite outgrowth using human SH-SY5Y neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA). Whereas BaP, at a concentration of 1 μM, had no significant effect on the viability of differentiating SH-SY5Y cells, the neurite outgrowth of differentiating SHSY5Y cells 48 h after BaP treatment was significantly inhibited. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.1–3 μM BaP resulted in decreased level of cross-reactivities with tissue glutaminase (TGase) antibody in a dose-dependent manner. To investigate the involvement of AhR signaling in the i.. View More»
  DOI: 10.4172/2161-0495.1000362

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