Caragea AM
Romania
Research Article
Telomerase Activity and Hepsin Gene Expression in Romanian Patients with Prostate Cancer: Preliminary Data
Author(s): Maruntelu I, Talangescu A, Rotarescu CA, Caragea AM and Constantinescu IMaruntelu I, Talangescu A, Rotarescu CA, Caragea AM and Constantinescu I
Purpose: Since PSA is not well associated with prostate cancer, there is a need in finding new more specific biomarkers for the diagnosis and/or follow-up prostate cancer patients. We have investigated the expression of telomerase activity and hepsin gene expressions in different prostate cancer tissues from Romanian patients. Prostate cancer diagnosis was revealed by total prostate-specific antigen levels and pathological assessments.
Patients and methods: We have selected 38 patients with proven biopsy prostate cancer (8 patients with metastasis and 30 patients without metastasis) and 20 patients with benign prostatic hyperplasia. The average age was 66.5 year in patients with PCa and 55.8 years in patients with BPH. Telomerase activity was analyzed with TRAPEzE ELISA Telomerase Detection (Millipore). Hepsin gene expression was revealed by R.. View More»