Andrology-Open Access
Open Access

Carol A. Podlasek

Publications

• Research Article
  Effect of Onabotulinum Toxin A on Substance P and Receptor Neurokinin 1 in the Rat Ventral Prostate
  Author(s): Omer Onur Cakir, Carol A. Podlasek, Douglas Wood, Kevin E. McKenna and Kevin T. McVary Omer Onur Cakir, Carol A. Podlasek, Douglas Wood, Kevin E. McKenna and Kevin T. McVary
  
  Introduction: The objective of this work is to examine if sensory innervation impacts lower urinary tract symptoms (LUTS). Onabotulinum toxin A (BoNTA) has been used for the treatment of overactive and neurogenic bladder and as a treatment for LUTS secondary to benign prostatic hyperplasia (BPH). The mechanism of how BoNTA impacts LUTS/BPH is unclear. In rats, BoNTA injection causes prostate denervation, apoptosis and atrophy. In clinical trials reduced prostate size and LUTS are observed inconsistently, suggesting a neurologic component. We will examine if BoNTA treatment inhibits substance P production in sensory nerve fibers in the rat prostate. Methods: Twenty Sprague Dawley rats were divided into four groups including 1X PBS (control, n=6), 2.5 units Onabotulinum toxin A (BoNTA, n=6), 5 units BoNTA (n=6) injected into both lobes of the ventral prostate (VP) and sham surgery (n=2).. View More»
  DOI: 10.4172/2167-0250.1000131

  Abstract PDF

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