Journal of Clinical and Cellular Immunology
Open Access

Carolina Francelin

Publications

• Review Article
  Apoptosis and the Developing T Cells
  Author(s): Carolina Francelin and Liana Verinaud Carolina Francelin and Liana Verinaud
  
  Efficient TCR repertoire selection in the thymus is critical for immune function, ensuring the production of functional MHC-restricted and self-tolerant T cells. T cell education in the thymus involves positive and negative selection processes where apoptosis play an especially important role in eliminating useless or potentially dangerous thymocytes. For decades, positive and negative selection in T cell development has attracted the attention and considerable research has been conducted to improve our understanding of how ligand induced signaling through the T cell receptor (TCR) can lead to both: rescue from death in the case of positive selection and death in the case of negative selection. In this brief report, we review the basic concepts involved in the extrinsic and intrinsic pathway of apoptosis, and provide an overview of the events that leads immature T cells to survive or .. View More»
  DOI: 10.4172/2155-9899.S3-001

  Abstract PDF

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