Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Carolina Francelin
Brazil
Review Article
Cytokines Expressed in the Granulomatous Lesions in Experimental Paracoccidioidomycosis: Role in Host Protective Immunity and as Fungal Virulence Factor
Author(s): Eva Burger, Angela Satie Nishikaku, Jacy Gameiro, Carolina Francelin, Zoilo Pires Camargo and Liana Verinaud
Eva Burger, Angela Satie Nishikaku, Jacy Gameiro, Carolina Francelin, Zoilo Pires Camargo and Liana Verinaud
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by the fungus Paracoccidioides brasiliensis (Pb). In the murine model of PCM, susceptible (S) mice develop disseminated disease with loose granulomas containing several viable fungi whereas resistant (R) mice show low fungal dissemination and encapsulated granulomas with few numbers of degenerated fungal cells. Here, we report the results of the expression of mRNA of these cytokines, as well as their distribution in the paracoccidioidomycotic granulomatous lesions and a semi quantitative score, that was correlated with the histological and biological data. Overall, our data show that the total area of granulomatous lesions and the relative areas of lesions containing Pb were, respectively, 1.2x and 1.9x more extensive in S than in the R mice. Also, the expression of IFN-γ and TNF-α mRNA was, r.. View More»
DOI:
10.4172/2155-9899.S1-010