Journal of Tumor Research
Open Access

Caterina Defendenti

Publications

• Research Article
  Immunoglobulin M Distribution and Modular Peptide Interactions in the Stroma of Human Colorectal Adenomas and Adenocarcinomas
  Author(s): Caterina Defendenti, Fabiola Atzeni, Sandro Ardizzone, Paolo Declich, Simone Saibeni, Emanuela Nebuloni, Simona Bollani, Savino Bruno, Valeria Lucini, Piero Luigi Almasio and Piercarlo Sarzi-PuttiniCaterina Defendenti, Fabiola Atzeni, Sandro Ardizzone, Paolo Declich, Simone Saibeni, Emanuela Nebuloni, Simona Bollani, Savino Bruno, Valeria Lucini, Piero Luigi Almasio and Piercarlo Sarzi-Puttini
  
  Background: Tissue organisation field theory explains that cancer starts as a result of an alteration in supporting tissue and inflammatory cells. The immunoglobulins (Igs) detected in colorectal adenocarcinomas come from the loss of integrity of resident μ chain-producing cells. Nearly half of the contact residues of Igs are aromatic and highly reactive. In the same way, the vast majority of cell surface proteins in the extra-cellular matrix contain a number of different domains or modules. The (Arg-Gly-Asp) RGD receptor domain of fibronectin constitutes cell adhesion receptors for cell-matrix adhesion and for bidirectional signaling across the membrane. Highly homologous oligopeptides emulate and compete with matrix adhesive proteins: Streptavidin binds to cells via the (Arg-Tyr- Asp) RYD mimetic RGD peptide. Furthermore, tyrosine-tryptophan-threonine-aspartic ac.. View More»
  DOI: 10.35248/2684-1258.17.3.133

  Abstract PDF

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