Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Célia M. M. B. de Castro
Brazil
Research Article
Analysis of Cytokines in Presumed Acute Infectious Endophthalmitis Following Cataract Extraction
Author(s): Paulo Escarião, Alessandra Goncalves Commodaro, Tiago Arantes, Célia M. M. B. de Castro, Maria de Fátima A. Diniz and Carlos Teixeira BrandtPaulo Escarião, Alessandra Goncalves Commodaro, Tiago Arantes, Célia M. M. B. de Castro, Maria de Fátima A. Diniz and Carlos Teixeira Brandt
Objective: To analyze the involvement of cytokines in acute infectious endophthalmitis following cataract extraction surgery.Methods: Vitreous humor samples were collected from 18 patients. The multiplex technique was used to measure IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, basic FGF, eotaxin, GCSF, GM-CSF, IFN-γ, MCP-1, MIP-1a, MIP-1b, PDGF-BB, RANTES, TNF-α and VEGF for comparison with levels in 39 patients undergoing vitrectomy for a non-infectious disease (control).Results: IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-9, IL-10, IL-15, IL-17, eotaxin, bFGF, G-CSF, GM-CSF, IFN-γ, MCP-1, MIP-1a, MIP-1b, PDGF-BB, RANTES and TNF-α levels were significantly higher (p <0.05) in eyes with endophthalmitis. There were no significant differences between groups for IL-.. View More»
DOI:
10.4172/2155-9570.1000335