Organic Chemistry: Current Research
Open Access

Chamakura VNS Varaprasad

Publications

• Research Article
  Generation of α-Linked Oligosaccharide Libraries by Random Glycosylation on Unprotected Acceptors
  Author(s): Yili Ding, Chamakura VNS Varaprasad, Shujian Huang, Jiedan Liao, Nan Zhang and Bingyun WangYili Ding, Chamakura VNS Varaprasad, Shujian Huang, Jiedan Liao, Nan Zhang and Bingyun Wang
  
  Background: The GlcNAc related disaccharides were reported to show inhibitory activity on breast tumor cells (MDAMB- 231). However, synthesis of disaccharides is lengthy, laborious and time consuming, and it is necessary to find more efficient methods to generate the disaccharide libraries. Random glycosylation has been an established practice to generate β-linked disaccharides library. Synthesis of α-linked disaccharide libraries by random glycosylation hasn’t been explored yet. We present our results on the synthesis of α-linked GlcNAc related disaccharide libraries by random glycosylation in this article. Results: Employing random glycosylation as a key step on an unprotected GlcNAc monosaccharide, and after deprotection and careful purification, few α-linked GlcNAc related disacchari.. View More»
  DOI: 10.4172/2161-0401.1000188

  Abstract PDF

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