Immunome Research
Open Access

Chang Chen

Publications

• Research Article
  The Evaluation of Toll-Like Receptors and Cytokines Expression in Human Langerhans Cells Indued by Zymosan
  Author(s): Xuelian Wang, Fangjie Fu and Chang Chen Xuelian Wang, Fangjie Fu and Chang Chen
  
  The aim of this study was to evaluate the modulatory effect of zymosan on human langerhans cells (LCs). The expression of Toll-like receptors (TLRs) and cytokines in LCs treated with zymosan was evaluated by determining the mRNA levels of TLR-1, TLR-2, TLR-4, TLR-9 and the mRNA levels of IL-1β, IL-6, IL-8, IL-10, IL-12, IL-23, TNF-α, and the protein level of bioactive IL-12p70. Furthermore, correlation coefficient of the mRNA levels of TLRs and cytokines was also evaluated to determine their mutual effects. The examined 10 samples showed significant increase in the mRNA level of those cytokines in all. As for TLRs, significant increase in TLR-2, decrease in TLR-1 and TLR-4 though the changing extent were slight and no significant difference in TLR-9 was shown. No significant increase of bioactive IL-12p70 protein was shown. All cytokines except for IL-12 were positively cor.. View More»
  DOI: 10.4172/17457580.1000139

  Abstract PDF

Relevant Topics