Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Cheng Wang
National Center for Toxicological Research, HFT-132, Food and Drug Administration , 3900 NCTR Road, Jefferson, AR 72079-0502,
Tanzania
Review Article
Critical Regulation of Calcium Signaling and NMDA-type Glutamate Receptor In Developmental Neural Toxicity
Author(s): Cheng Wang
Cheng Wang
Calcium (Ca2+) is a vital element in the process of neurotransmitter release, and is a common signaling mechanism. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger.
Glutamate receptors play an important role in the excitatory synaptic action of the central nervous system. Activation of the N-methyl-D-aspartate (NMDA)-type glutamate receptor increases the concentration of (Ca2+) in the cell. Ca2+ can in turn function as a second messenger in various signaling pathways.
The developing nervous system varies in susceptibility to neurotoxic insults depending on the stage of development. By monitoring alterations in calcium influx, cell signaling processes, expression levels of receptor subtypes and imaging outcomes, it may be possible to completely define the affected system(s) during development.
This review attempts to.. View More»
DOI:
10.4172/2157-7609.1000151