Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Cheng-cheng Guo
China
Review Article
Clinical Practice Of Chemotherapy With Temozolomide In China
Author(s): Cheng-cheng Guo, Qun-ying Yang, Ke Sai and Zhong-ping ChenCheng-cheng Guo, Qun-ying Yang, Ke Sai and Zhong-ping Chen
The treatment for malignant tumors in the central nervous system (CNS) mainly consists of surgical resectionfollowed by adjuvant radiation and chemotherapy. Temozolomde (TMZ), a second-generation of oral alkylatingagent, plays an increasingly important role in the treatment of malignant glioma in China. However, the history ofTMZ use in China, has not been well reviewed. In this study, an extensive literature search of Pubmed and majorChinese electronic databases was performed to identify clinical reports on TMZ use in mainland China. We foundthat TMZ is a standard addition to postoperative RT for glioblastoma, followed by 6 cycles of adjuvant treatments asChinese and NCCN guidelines recommended. But since TMZ is relatively expensive to most Chinese patients,especially in undeveloped areas, some other regimens are still commonly used. It is also indicated for relapsed orGrade III glio.. View More»
DOI:
10.4172/2167-7700.1000129