Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Cheng-Yuan Huang
Canada
Research Article
Potential Roles of Cancerous Immunoglobulins in the Immunology of Cancer Cells
Author(s): Gregory Lee, Cheng-Yuan Huang, Yiting Tang and Hao ZhangGregory Lee, Cheng-Yuan Huang, Yiting Tang and Hao Zhang
Expressions of immunoglobulins among various cancer cells have been known for decades. However, their potential roles and mechanisms of action are not fully understood and need further investigations. A monoclonal antibody designated as RP215 was found to react mainly with the carbohydrate-associated epitope of antigen receptors including immunoglobulins and T cell receptors on the surface of cancer cells, but not in normal immune cells. Therefore, RP215 was used as a probe to replace antibodies against cancerous immunoglobulins to study their roles in the immunology of cancer cells, through extensive biochemical and immunological studies. Both antigen ligands were found to have high correlations in terms of regulations of a number of genes involved in growth/proliferation of cancer cells (e.g. NFκB-1, IgG, P21, Cyclin D1, ribosomal P1 and c-fos) as well as toll-like receptors. T.. View More»
DOI:
10.4172/2155-9899.1000200