Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Chiang JM
Chang Gung Memorial Hospital, and College of Medicine,
Tao-yuan
People's Republic of China
Research Article
“Real World” Effectiveness of Different Postoperative Adjuvant
Chemotherapy Regimens in Stage III Colon Cancer Patients
Author(s): Chiang JM, Hung HY, Chiang SF, You JF, Pao-Shiu Hsieh and Chien-Yuh Yeh
Chiang JM, Hung HY, Chiang SF, You JF, Pao-Shiu Hsieh and Chien-Yuh Yeh
Background: The benefit of oxaliplatin as postoperative adjuvant chemotherapy in the real world practice remained further clarified. Clinically, choosing oral 5-FU drug or FOLFOX regimen may depend to drug toxicity and patient’s age and comorbidities.
Methods: Patients included in this study was from Chang Gung Memorial Hospital (CGMH) colorectal cancer registry database. Treatment outcomes were compared based on the type of chemotherapy in terms of OS and DFS. Multivariate Cox-regression modelling was used to adjust for the potential confounders.
Results: Between 2007 Jan and 2012 Dec, 688 stage III colon cancer patients were collected including fluorouracil-leucovorin plus oxaliplatin (FOLFOX-6) (283 patients), Capecitabine (259 patients), and Tegafur-uracil (146 patients)... View More»
DOI:
10.4172/2167-7700.1000211