Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Choon Hyuck David Kwon
Taiwan
Research Article
Combination Therapy of Sirolimus and Sorafenibfor Recurrent
Hepatocellular Carcinoma after Liver Transplantation
Author(s): Wontae Cho, Jong Man Kim, Jin Yong Choi, Seung Hwan Lee, Hyung Hwan Moon, Sanghoon Lee, Jae Berm Park, Choon Hyuck David Kwon, Jae-Won Joh, Sung Joo Kim and Suk-Koo LeeWontae Cho, Jong Man Kim, Jin Yong Choi, Seung Hwan Lee, Hyung Hwan Moon, Sanghoon Lee, Jae Berm Park, Choon Hyuck David Kwon, Jae-Won Joh, Sung Joo Kim and Suk-Koo Lee
Backgrounds: Sirolimus and sorafenib both have been used in recurrent Hepatocellular Carcinoma (HCC) patients after Liver Transplantation (LT). In the present study, we evaluated the side effects and efficacy of acombination therapy consisting of sirolimus and sorafenib.
Methods: We retrospectively reviewed patients who had recurrent HCC after LT between 2005 and 2012. Toxicity was evaluated by reviewing medical records for each follow-up visit. Efficacy was evaluated according to the modified RECIST guidelines.
Results: A total of 24 patients who received combination therapy were reviewed to evaluate drug toxicity. Side effects included hand-foot syndrome (n=12, 50%), diarrhea (n=7, 29.2%), fatigue (n=2, 8.3%), and alopecia (n=1, 4.2%). Among the 24 patients enrolled in this study, 19 were evaluated for efficacy. .. View More»
DOI:
10.4172/2167-7700.1000118