Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Christina H. Stuelten
National Institutes of Health, National Cancer Institute, Laboratory of Cellular and Molecular Biology,
37 Convent Drive, Bethesda, MD 20892
Tanzania
Review Article
Moving in and Out: Dispersion of Cells in Self-Generated Gradients
Author(s): Christina H. StueltenChristina H. Stuelten
Migrating cells can influence the direction of their own migration by metabolizing chemoattractants present in their environment. This is illustrated by the dispersal of melanoma cells, which break down lysophosphatidic acid and generate a gradient with increasing concentrations of lysophosphatidic acid distant from the tumor. Melanoma cells can then disperse away from the tumor as they migrate in the self-generated lysophosphatidic acid gradient. Thus, dispersal of tumor cells during invasion of the surrounding stroma might be driven by chemotaxis of cells along self-generated chemoattractant gradients... View More»
DOI:
10.4172/2155-9899.1000507