Journal of Clinical Toxicology
Open Access

Christopher J Edwards

Publications

• Case Report
  Sodium Acetate as an Alkalinizing Agent for Salicylate Intoxication: A Case Report
  Author(s): Steven F Groke, Daniel H Jarrell, Christopher J Edwards, Peter B Chase, Mark J Murphy and Frank G Walter Steven F Groke, Daniel H Jarrell, Christopher J Edwards, Peter B Chase, Mark J Murphy and Frank G Walter
  
  Background: Urine and serum alkalization with sodium bicarbonate (NaHCO3) is the initial treatment for salicylate toxicity. Due to medication shortages, sufficient quantities of NaHCO3 may not be available and alternative treatments may be needed. Case Report: This is an observational case report of a man who presented with chronic, inadvertent aspirin intoxication. Initially, we used a NaHCO3 continuous intravenous (IV) infusion until the hospital ran out of NaHCO3. Thereafter, the NaHCO3 IV infusion was replaced with a sodium acetate (SA) continuous IV infusion. “Why should an emergency physician be aware of this?” Sodium acetate’s role in serum and urine alkalization for drug intoxications is not well understood. Physiologically, SA is converted to acetyl-coA and processed through the Krebs cycle, producing CO2.. View More»
  DOI: 10.4172/2161-0495.1000237

  Abstract PDF

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