Journal of Clinical & Experimental Dermatology Research
Open Access

Christos C Zouboulis

Publications

• Research Article
  Effects of Isotretinoin on the Phosphoinositide-3-kinase/Akt/FoxO1 Pathway and Molecular Functions of SZ95 Sebocytes In vitro
  Author(s): Yasaman Mirdamadi, Anja Thielitz, Antje Wiede, Alexander Goihl, Christos C Zouboulis, Ursula Bommhardt, Sven Quist, Harald Gollnick Yasaman Mirdamadi, Anja Thielitz, Antje Wiede, Alexander Goihl, Christos C Zouboulis, Ursula Bommhardt, Sven Quist, Harald Gollnick
  
  Objective: For more than 3 decades, isotretinoin [13-cis retinoic acid (13-cis RA)] is established as the most potent oral treatment for severe acne. However, the molecular mechanisms of isotretinoin action have not been fully elucidated. Recently, we showed that insulin and insulin-like growth factor 1 (IGF-1) increase differentiation and decrease proliferation of SZ95 sebocytes in vitro via activation of the phosphoinositide 3-kinase (PI3K)/Akt/forkhead box-O1 (FoxO1) pathway. Furthermore, this pathway is activated in patient acne biopsies in vivo. Using SZ95 sebocytes as an in vitro model, the aim of this study was to investigate the effect of isotretinoin on PI3K pathway activation. Methods: SZ95 sebocytes were treated under light protection with 0.1 μM isotretinoin in the presence or absence of 1.0 and 0.1 μM IGF-1 or insulin or 50 &.. View More»
  DOI: 10.4172/2155-9554.1000399

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