Journal of Clinical and Cellular Immunology
Open Access

Christos Kosmas

Publications

• Case Report
  Complete Remission of Progressive SLE after High-dose Chemotherapy and Autologous Hematopoietic Cell Transplantation for Relapsed Non-seminomatous Germ Cell Tumor
  Author(s): Christos Kosmas, Theodora Papachrysanthou, Theodoros Daladimos, Nicolas Tsavaris and Panayiotis Vlachoyiannopoulos Christos Kosmas, Theodora Papachrysanthou, Theodoros Daladimos, Nicolas Tsavaris and Panayiotis Vlachoyiannopoulos
  
  Objective: High dose chemotherapy and hematopoietic stem cell support remains a curative and accepted treatment option for relapsed or non-responsive germ cell tumors, and has been applied experimentally to control severe life-threatening autoimmune diseases. Case Report: In the present study, we report on a patient with systemic lupus erythematosous nephritis, not controllable with monthly cyclophosphamide pulses followed by immunosuppressive treatment with mycophenolate mofetil, developing a non-seminomatous germ cell tumor that had relapsed after standard chemotherapy and surgery. The patient received salvage chemotherapy with paclitaxel-ifosfamide-cisplatin (TIP) with G-CSF support for three cycles and hematopoietic stem cells were mobilized and harvested with leukapheresis after the first TIP cycle. This was followed by high-dose chemother.. View More»
  DOI: 10.4172/2155-9899.1000203

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