Clinical & Experimental Cardiology
Open Access

Clemens Kern

Publications

• Research Article
  A Prospective Randomised Study of Postoperative Prophylactic Application of Sildenafil After Pediatric Cardiac Surgery
  Author(s): Anna Hofer, Martina Heschl, Clemens Kern, Eva Grohmann, Eva Sames-Dolzer, Hans Gombotz and Jens Meier Anna Hofer, Martina Heschl, Clemens Kern, Eva Grohmann, Eva Sames-Dolzer, Hans Gombotz and Jens Meier
  
  Postoperative aggravation of pulmonary hypertension after pediatric cardiac surgery due to temporary endothelial dysfunction may lead to sudden pulmonary arterial pressure rise with compromise of right ventricular function. Though treatment with inhaled nitric oxid (NO) has been successful, rebound pulmonary hypertension has been observed after NO withdrawal due to supression of endogenous NO sythase. Sildenafil has been shown to prevent this reaction and is widely used after pediatric cardiac surgery. The aim of our study was to evaluate the effectively of postoperative administration of oral sildenafil (1 mg/kg/day) in preventing postoperative pulmonary hypertensive crises. 21 patients after repair of complete atrioventricular canal (n=10) or ventricular septal defect (n=11) were randomly assigned to the study group or control group. The study group received sildenafil after surgery.. View More»
  DOI: 10.4172/2155-9880.1000392

  Abstract PDF

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