McPherson Eye Research Institute University of Wisconsin-Madison and Chippewa Valley Eye Clinic, USA
Biography
Alzheimer’s Disease (AD) is mostly regarded as Alzheimer’s disease dementia. AD is diagnosed with certitude at autopsy or via brain biopsy. However, it is now known that the AD pathological abnormalities, detected in vivo by biological markers, precede the clinical symptoms by years or even decades. The uniform lack of success in treating AD may be due to the fact that therapeutic intervention is begun too late in the course of the disease. The earliest recognizable pathological event in AD is aggregated cerebral amyloid-β deposition; this pathology may be present 20 years before the onset of dementia
