Journal of Proteomics & Bioinformatics
Open Access

Coby Laarakkers

Publications

• Research Article
  Potential New Markers of Inflammation-Induced Renal Injury Subside when Endotoxin Tolerance Develops in Humans
  Author(s): Rosalinde Masereeuw, Annelies Draisma, Suzanne Heemskerk, Martijn PWJM Bouw, Coby Laarakkers, Johannes G van der Hoeven and Peter Pickkers Rosalinde Masereeuw, Annelies Draisma, Suzanne Heemskerk, Martijn PWJM Bouw, Coby Laarakkers, Johannes G van der Hoeven and Peter Pickkers
  
  Purpose: Cytokines play an important role in the development of renal injury during sepsis. Because of its high mortality rate, early detection of inflammation-induced renal injury is of critical importance. Methods: We used Surface enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI- -TOF MS), to search for new biomarkers for early renal injury during acute systemic inflammation, and after development of endotoxin tolerance in humans in vivo. Results: Repeated LPS administrations induced a 33 ± 7% decrease in glomerular filtration rate (p=0.02) on day 2, and an increase in serum creatinine of 11 ± 3% (p=0.002) on day 3, which was associated with the appearance of 15 peak intensities in the urinary protein profile, including an increase in ß2-microglobuline levels (p=0.04), 6 hours after the first LPS administration. Fou.. View More»
  DOI: 10.4172/jpb.1000262

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