Journal of Proteomics & Bioinformatics
Open Access

Colin D. Crean

Publications

• Research Article
  Proteomic Characterization of Plasma Cells from Patients with Multiple Myeloma
  Author(s): Attaya Suvannasankha, Colin D. Crean, Heather M. Leyes, Sariya Wongsaengsak, Guihong Qi, Jong-Won Kim and Mu Wang Attaya Suvannasankha, Colin D. Crean, Heather M. Leyes, Sariya Wongsaengsak, Guihong Qi, Jong-Won Kim and Mu Wang
  
  Introduction: Quantitative proteomics approaches have provided insight into biomarkers of cancer and other diseases with high sensitivity, high specificity, and high analytical precision. Multiple Myeloma is an incurable, fatal blood cancers characterized by clonal expansion of plasma cells in the bone marrow. Current multiple myeloma proteomic research mainly focuses on serum biomarkers, not plasma cells, due to technical difficulties including a requirement for tumor cell isolation from bone marrow aspirates, tumor cell paucity and poor in vitro survival after isolation. Materials and methods: A global proteomic analysis was performed using sorted bone marrow plasma cells from normal donors and multiple myeloma patients and a large-scale quantitative mass spectrometry platform. A selected panel of up- and down-regulated proteins were validate.. View More»
  DOI: 10.4172/jpb.1000461

  Abstract PDF

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