Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Research Article
Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients
Author(s): Juan C. Andreu-Ballester, Constantino Tormo-Calandín, Carlos Garcia-Ballesteros, Victoria Amigo, Ana Peiró-Gómez, Juan Ruiz del Castillo, Carlos Peñarroja-Otero, Ferran Ballester, Soledad Fenoy, Carmen del Aguila and Carmen CuéllarJuan C. Andreu-Ballester, Constantino Tormo-Calandín, Carlos Garcia-Ballesteros, Victoria Amigo, Ana Peiró-Gómez, Juan Ruiz del Castillo, Carlos Peñarroja-Otero, Ferran Ballester, Soledad Fenoy, Carmen del Aguila and Carmen Cuéllar
Objective: We recently demonstrated that the biggest reduction of T cells in septic patients was produced in the γδ T subset. This depletion was directly proportional to the severity of the septic process, and it was associated with mortality. We hypothesized that microsporidia can harness the deficit of γδ T cells in septic patients to proliferate and contribute to the worsening of the sepsis. Methods: In this retrospective study, we analyzed anti-Encephalitozoon cuniculi antibody levels in sera from 46 septic patients, and compared them with a similar control group of healthy subjects. As a secondary objective we aimed to relate anti-E. cuniculi antibody levels with αβ and γδ T cells in these patients. Results: Forty-eight percent of septic patients were positive .. View More»
DOI:
10.4172/2155-9899.1000244