Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Costin Petcu
Romania
Review Article
Are MicroRNAs Reliable Prognostic Biomarkers in Liver Hepatocellular Carcinoma Development?
Author(s): Ileana Constantinescu, Costin Petcu and Maria Mirela IacobIleana Constantinescu, Costin Petcu and Maria Mirela Iacob
Hepatocellular Carcinoma (HCC) is a complex multi-step process which involves genetic and epigenetic alterations. This disease is often not detected until late in development. It is necessary to discover and validate new sensitive, non-invasive, diagnostic and prognostic biomarkers able to highlight changes in disease status and liver function. Deregulation of microRNAs activity plays an important role in pathogenesis of chronic Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) infections, Non-alcoholic Fatty Liver Disease (NAFLD) and in the progression to HCC. The assessment of serum microRNAs profiles may provide insights related to the chronic viral hepatitis molecular mechanism which could lead to HCC. MicroRNAs are involved in controlling the metabolic pathways of infected cells and also the immune-metabolic response to viral infection in the liver. Also, microRNAs are crucial reg.. View More»