Pancreatic Disorders & Therapy
Open Access

Crystal DuPont

Publications

• Editorial
  CAR-T: Expression, Expansion, and Clinical Applications
  Author(s): Crystal DuPont, Rehan Muhammad and Jiazhi SunCrystal DuPont, Rehan Muhammad and Jiazhi Sun
  
  Understanding and treating cancer is one the top priorities in medical research. The use of chimeric antigen receptor T-cells (CAR-T) are increasing in popularity in the research and treatment of cancer due to their ability to utilize the expansion and killing effects of cytotoxic T cells while also having binding specificity through the chimeric antigen receptor (CAR). CAR expression and CAR-T expansion are critical for proper CAR-T functionality. Toxicity has been associated with the treatment of cancers with CAR-T however methods to control and decrease toxicity have been developed. While they first became popular for the treatment of B-cell lymphomas they are expanding to the treatment of other cancers. In this review we will discuss the current methods for CAR-T expansion, expression, and toxicity prevention while also covering current clinical applications of this therapy. .. View More»
  DOI: 10.4172/2165-7092.S5e001

  Abstract PDF

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