Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Daehyun Kim
Taiwan
Research Article
The Influence of Ramosetron on the Analgesic Effect of Tramadol
Author(s): Yanghyun Kim, Daehyun Kim, Takkyu Oh, Eunju Seo, Junsun Ryu and Yuhseok JungYanghyun Kim, Daehyun Kim, Takkyu Oh, Eunju Seo, Junsun Ryu and Yuhseok Jung
Background: The 5-hydroxytryptamine-3 antagonist antiemetics block the analgesic effect of tramadol. This prospective, randomized single-blinded study was designed to investigate the interaction between ramosetron and tramadol in females undergoing thyroidectomy. Method: We randomized 128 patients into two groups to receive ramosetron-tramadol (group R) or normal saline-tramadol (group N). Intravenous ramosetron (0.3 mg) or normal saline was administered at the induction of anesthesia, and 50 mg tramadol were given intravenously for postoperative analgesia 30 min before extubation. The analgesic regimen in the post-anesthesia care unit included additional 50 mg doses of tramadol if pain scores were >40 at rest. Postoperative pain was evaluated using an 11-point visual analog scale at 1 and 24 h postoperatively. Pain and nausea scores, analgesic and antiemetic doses, side effects, p.. View More»
DOI:
10.4172/2155-6148.1000483