Dalia A Sabry
Egypt
Research Article
Deca Durabolin (Nandrolone Decanoate) Impair Structure and Function of Liver, Prostate and Pituitary of Male Wistar Rats
Author(s): Abdelalim A Gadallah, Heba A El-Ghawet and Dalia A Sabry
Abdelalim A Gadallah, Heba A El-Ghawet and Dalia A Sabry
Anabolic-androgenic steroids have been widely used by athletes for performance and body building. The present study was carried out to illustrate the cytotoxic effects of nandrolone decanoate on liver, gonadotroph, somatotroph and corticotrophin cells and their correlations to prostate structure and function. Deca-durabolin (nandrolone decanoate) was intramuscular administered (every three days for three months) to male Wistar rats (100 g body weight) at two dose levels; low (4 mg/kg) and high dose-treatment (8 mg/kg body weight). At the end of treatment, the liver, prostate and pituitary were dissected and subjected for histological and transmission electron microscopy and isoenzyme electrophoresis of alkaline and acid phosphatase, glucose-6-phosphate dehydrogenase, sorbitol dehydrogenase, maleic dehydrogenase and lactic dehydrogenase.
The present finding revealed pathologi.. View More»