Journal of Drug Metabolism & Toxicology
Open Access

Daniel Kuzman

Publications

• Research Article
  Drug Interactions Involving the Cytochrome P450 Enzymes: Analysis of Common Combinations of Antibiotics and Pain Relieving Drugs
  Author(s): Saskia Preissner, Daniel Kuzman and Nicole PischonSaskia Preissner, Daniel Kuzman and Nicole Pischon
  
  Objective: For clinicians it is challenging to oversee complex drug interactionsof multi-drug administration. Rheumatoid arthritis (RA) patients are frequently under long-term medication with multiple anti-inflammatory and pain-relieving drugs, which are mainly metabolized by the Cytochrome P450 enzymes (CYPs). Additionally, treatment of co-morbidities, such as inflammatory periodontal disease (PD) may have to involve further drug administration. The aim of this investigation was to analyze drug interactions in the therapy of RA and PD and to provide a resource for health professionals to easily check interactions and avoid potential side effects. Methods: Information on drug administration in the therapy of RA and PD and expression data of human tissues regarding CYPs was gathered and/or analyzed from scientific literature and web resources. A literature compilation was developed and.. View More»
  

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