Family Medicine & Medical Science Research
Open Access

Daniel Laskowski

Publications

• Commentary
  Oral Sildenafil has No Acute Effect on Diffusion Capacity Measurements in Patients with Diffuse Parenchymal Lung Disease and Pulmonary Hypertension
  Author(s): Isabel Mira-Avendano, Umur Hatipoglu, Catherine Sant, Daniel Laskowski, Ruchi Yadav and Raed Dweik Isabel Mira-Avendano, Umur Hatipoglu, Catherine Sant, Daniel Laskowski, Ruchi Yadav and Raed Dweik
  
  Diffuse parenchymal lung diseases have diverse etiology and treatment often requires individualization taking into consideration comorbidities. Pulmonary hypertension represents one such comorbidity which, when present, worsens prognosis and confounds approach to treatment. Sildenafil is a pulmonary vasodilator, which has recently generated considerable interest for use in patients with diffuse parenchymal lung disease and concomitant pulmonary hypertension. We wondered whether acute administration of oral sildenafil affects the diffusion capacity measurement, which is a tool for serially monitoring patients with diffuse parenchymal lung diseases. Methods: 15 patients with diffuse parenchymal lung disease and pulmonary hypertension (WHO Class III) had diffusion capacity measurements and 6 minute walk test performed before and after receiving sildenafil 20 mg orally. CT scans.. View More»
  DOI: 10.4172/2327-4972.1000173

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