Family Medicine & Medical Science Research
Open Access

David D McManus

Publications

• Review Article
  Circulating Cell and Plasma microRNA Profiles Differ between Non-STSegment and ST-Segment-Elevation Myocardial Infarction
  Author(s): Jeanine A Ward, Nada Esa, Rahul Pidikiti, Jane E Freedman, John F Keaney, Kahraman Tanriverdi, Olga Vitseva, Victor Ambros, Rosalind Lee and David D McManusJeanine A Ward, Nada Esa, Rahul Pidikiti, Jane E Freedman, John F Keaney, Kahraman Tanriverdi, Olga Vitseva, Victor Ambros, Rosalind Lee and David D McManus
  
  Background: Differences in plasma and whole blood expression microRNAs (miRNAs) in patients with an acute coronary syndrome (ACS) have been determined in both in vitro and in vivo studies. Although most circulating miRNAs are located in the cellular components of whole blood, little is known about the miRNA profiles of whole blood subcomponents, including plasma, platelets and leukocytes in patients with myocardial ischemia. Methods: Thirteen patients with a ST-segment-elevation (STEMI) or non-ST-segment elevation (NSTEMI) myocardial infarction were identified in the University of Massachusetts Medical Center Emergency Department (ED) or cardiac catheterization laboratory between February and June of 2012. Whole blood was obtained from arterial blood samples at the time of cardiac catheterization and cell-specific miRNA profiling was performed... View More»
  DOI: 10.4172/2327-4972.1000108

  Abstract PDF

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