Journal of Clinical Toxicology
Open Access

David J. Hutchinson

Publications

• Research Article
  Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study
  Author(s): Marilyn E. Morris, Bridget L. Morse, Gloria J. Baciewicz, Matthew M. Tessena, Nicole M. Acquisto, David J. Hutchinson and Robert DiCenzoMarilyn E. Morris, Bridget L. Morse, Gloria J. Baciewicz, Matthew M. Tessena, Nicole M. Acquisto, David J. Hutchinson and Robert DiCenzo
  
  Background and objective: The purpose of the current study was to demonstrate proof-of-concept that monocarboxylate transporter (MCT) inhibition with L-lactate combined with osmotic diuresis increases renal clearance of ?-hydroxybutyrate (GHB) in human subjects. GHB is a substrate for human and rodent MCTs, which are responsible for GHB renal reabsorption, and this therapy increases GHB renal clearance in rats Methods: Ten healthy volunteers were administered GHB orally as sodium oxybate 50 mg/kg (4.5 gm maximum dose) on two different study days. On study day 1, GHB was administered alone. On study day 2, treatment of L-lactate 0.125 mmol/kg and mannitol 200 mg/kg followed by L-lactate 0.75 mmol/kg/hr was administered intravenously 30 minutes after GHB ingestion. Blood and urine were collected for 6 hours, analyzed for GHB, and pharmacokinetic and statistical analyses performed. R.. View More»
  DOI: 10.4172/2161-0495.1000105

  Abstract PDF

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