Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
David Jobes
Tanzania
Research Article
Plasma and Tissue Pharmacokinetics of Cefazolin in an Immature Porcine Model
of Pediatric Cardiac Surgery
Author(s): Todd Kilbaugh, Adam S Himebauch, Theoklis Zaoutis, David Jobes, William Greeley, Susan C Nicolson and Athena F Zuppa
Todd Kilbaugh, Adam S Himebauch, Theoklis Zaoutis, David Jobes, William Greeley, Susan C Nicolson and Athena F Zuppa
Background: Surgical Site Infection (SSI) prevention for children with congenital heart disease is imperative and
methods to assess and evaluate the tissue concentrations of prophylactic antibiotics are important to help maximize
these efforts. The purpose of this study was to determine the plasma and tissue concentrations of standard-of-care
peri-operative cefazolin dosing in an immature porcine model of cardiac surgery and cardiopulmonary bypass.
Methods: Piglets (3-5 days old) underwent either median sternotomy (MS) or cardiopulmonary bypass with deep
hypothermic circulatory arrest (CPB+DHCA) and received standard of care prophylactic cefazolin for the
procedures. Serial plasma and microdialysis sampling of skeletal muscle and subcutaneous tissue adjacent to the
surgical site was performed. Cefazolin concentrations were measured, non.. View More»
DOI:
10.4172/2155-6148.1000508