Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Debasu Damtie
School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences,
Gondar
Ethiopia
Review Article
Review on Molecular Mechanism of First Line Antibiotic Resistance in Mycobacterium tuberculosis
Author(s): Debasu Damtie, Desalegn Woldeyohannes and Biniam Mathewos
Debasu Damtie, Desalegn Woldeyohannes and Biniam Mathewos
Tuberculosis (TB) is among the most common infectious diseases and frequent causes of death worldwide claiming many of lives annually. The problem of tuberculosis is hampered by the emergence of multi drug resistant(MDR) and extensively drug resistant (XDR) tuberculosis. Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic Mycobacterium tuberculosis they also select for drug resistant bacteria against which those drugs are then ineffective.
In contrast to other bacteria, resistance of M. tuberculosis is exclusively associated with chromosomal mutations. Globally, the emergence of multidrug-resistant strains of M. tuberculosis is an increasing problem which adversely affects patient care and public health. The objective of this review is therefore to compile available literatures about the drug resistance mechanisms of M... View More»
DOI:
10.4172/2161-1068.1000174